Sequence editors for biologists on Linux
Sequence editors for biologists on Linux - Conclusion Print E-mail
Friday, 05 October 2007 09:10
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Conclusion

I've now been working with CLC Free Workbench for six months and I am still happy with it. Although it features relatively basic functions, I found a software that was free and matched my needs for everyday's work as a molecular biologist.

CLC Combined Workbench

As I mentioned above CLC Free Workbench is in fact a free teaser to advertise for CLC Bio's software suite, CLC Combined Workbench. Although I did not test it, the Combined Workbench contains functions for BLAST searches, primers design, chromatogram viewing, 3D molecular modeling and more... It seems really nice! I would definitely have purchased it if it was sold for a few hundred dollars. However the price is still prohibiting for me: 2250 USD for an academic license (4500 USD for a comercial license). The price may be lowered to 1500 USD (3000 USD for a commercial license) by purchasing only one of the three sets of tools (for DNA, RNA and protein sequences) which are comprised in CLC Combined Workbench... Well, anyway I need features from at least two of them...

Geneious

To my knowledge, no free comparable GUI biological sequence manager is available for Linux at present time. Note that I precise "free" as another Java-based software exists, I named Geneious (Developed by Biomatters Ltd). I was thinking at first of writing a comparison between the two softwares, but the free version of Geneious does not compare to CLC Free Workbench. It is merely a demo version with a 14 days trial which is not suitable for the basic needs of a biologist. This may come from the fact that the marketing strategies behind the two suites are somewhat different: While CLC Combined Workbench is relatively expensive, its free version is well equiped. On the other hand, the free Geneious version consists only of a demo, but the full software is relatively less expensive (249 USD for students, 495 USD for academics and 995 USD for commercials).



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molgyk  - CLC free workbench 4.0.3   |2007-10-30 20:01:16
A new version (4.0.3) of CLC free workbench has been released mainly to fix some bugs. The installation procedure and the interface are still the same.
misha680  - Vector NTI runs very well in wine   |2007-12-13 07:17:33
Btw, thanks to some work myself and others have done in the previous year, Vector NTI actually runs very well in Wine, and this is definitely an alternative for people using Ubuntu. Basically, it's as simple as really just double-clicking on the installer if you have Wine installed (just "sudo aptitude install wine" first will do); if you'd like a little more of the tools menu (Web ordering) you'll have to dig around for mfc42.dll on google and (i) run "wine" with no parameters to create ~/.wine, (ii) copy mfc42.dll to ~/.wine/drive_c/windows/system32, and (iii) double-click on the installer. Only real big thing not working is online help. Hope this helps.
molgyk  - Thanks for the precision   |2007-12-13 13:33:11
I must say I only tried more than a year ago to run Vector NTi under Wine. By the time, it was not working as simply and I did not check for news since then. It's really good to hear that it may now be run under Linux! Thanks for the post.

A tiny question though: what version of Vector NTi runs now in Wine (if not all)?
misha680  - Which version?   |2008-01-15 00:27:00
Sorry didn't mention the version number. The latest that is downloadable from Invitrogen Vector NTI Advance 10 now works very well (perfectly except no online help index/searching, only context-based) on wine. I use it almost every day.
Geneious Developer  - Geneious doesn't only include a demo   |2008-04-08 07:03:20
When you download Geneious, it runs as Geneious Pro for 14 days and then reverts to Geneious Basic. You can continue to use Geneious Basic for as long as you want, so it's not just a demo as you say.

Also, unlike CLC the free version of Geneious will occasionally (about once in 8 days I think, but not in regular intervals) give you free use of the Pro features - it's called "Geneious Day".

Also, a new version 3.6.2 of Geneious is out and contains loads of new features and improvements.
molgyk  - Geneious   |2008-04-14 22:03:52
Thanks for the comment.

My post is becoming a bit old. Still, when I tested Geneious (I should have mentioned the version), I just thought the free "demo" version was not suitable for the simple everyday needs of a molecular biologist.

That said, I'll be glad to test the new features of Geneious soon!
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